In witness whereof

IN WITNESS WHEREOF, the Corporation has caused these presents to be signed in its name and on its behalf by its President and Assistant Secretary on November 18, 2020. The undersigned President and Assistant Secretary acknowledge that these Articles Supplementary are the act of the Corporation, that to the best of their knowledge, information and belief, all matters and facts set forth herein relating to the authorization and approval of these Articles of Supplementary are true in all material respects and that this statement is made under the penalties of perjury.

IN WITNESS WHEREOF, Federated Investment Series Funds, Inc. has caused these Articles of Amendment to be signed in its name and on its behalf as of June 19, 2020, by its duly authorized officers, who acknowledge that these Articles of Amendment are the act of the Corporation, that to the best of their knowledge, information and belief, that matters and facts set forth herein relating to the authorization and approval hereof are true in all material respects, and that this statement is made under the penalties of perjury.

IN WITNESS WHEREOF, Investment Series Funds, Inc. has caused these Articles of Amendment to be signed in its name and on its behalf as of January 13, 2000, by its duly authorized officers, who acknowledge that these Articles of Amendment are the act of the Corporation, that to the best of their knowledge, information and belief, all matters and facts set forth therein relating to the authorization and approval of these Articles are true in all material respects, and that this statement is made under the penalties of perjury.

KNOW ALL PERSONS BY THESE PRESENT, that the undersigned, in his capacity as a director/trustee of the above-referenced organizations listed on Appendix A hereto (the “Funds”), hereby constitutes and appoints MARK J. CZARNIECKI, DIANA R. GONZALEZ, KEVIN J. McCARTHY, CHRISTOPHER M. ROHRBACHER, MARK L. WINGET and ERIC F. FESS, and each of them (with full power to each of them to act alone) his true and lawful attorney-in-fact and agent, for him and on his behalf and in his name, place and stead, in any and all capacities, to sign, execute and file the Funds’ Registration Statements on Form N-2 under the Securities Act of 1933 and the Investment Company Act of 1940 registering shares of the Funds, including any pre-effective and post-effective amendments thereto, with all exhibits, and any and all other documents required to be filed with any regulatory authority, federal or state, relating to the registration thereof, or the issuance of shares thereof, without limitation, granting unto said attorneys, and each of them, full power and authority to do and perform each and every act and thing requisite and necessary to be done in and about the premises in order to effectuate the same as fully to all intents and purposes as he might or could do if personally present, hereby ratifying and confirming all that said attorneys-in-fact and agents, or any of them, may lawfully do or cause to be done by virtue hereof. IN WITNESS WHEREOF, the undersigned director/trustee of the above-referenced organizations has hereunto set his hand this 19th day of November 2020.

IN WITNESS WHEREOF, Federated Fixed Income Securities, Inc. has caused these presents to be signed in its name and on its behalf as of October 13, 2000, by its duly authorized officers, who acknowledge that these Articles Supplementary are the act of the Corporation, that to the best of their knowledge, information and belief, all matters and facts set forth herein relating to the authorization and approval of these Articles are true in all material respects, and that this statement is made under the penalties of perjury.

The undersigned director of Sun BioPharma, Inc., a Delaware corporation (the “Company”), does hereby make, constitute and appoint Michael T. Cullen and Susan Horvath, and either of them individually, the undersigned’s true and lawful attorneys-in-fact, with power of substitution, for the undersigned and in the undersigned’s name, place and stead, to sign and affix the undersigned’s name as such director and/or officer of said corporation to an Annual Report on Form 10-K for the fiscal year ended December 31, 2019 or other applicable form, and all amendments thereto, to be filed by the Company with the Securities and Exchange Commission, Washington, D.C., under the Securities Act of 1934, as amended, with all exhibits thereto and other supporting documents, with said Commission, granting unto said attorneys-in-fact, and either of them, full power and authority to do and perform any and all acts necessary or incidental to the performance and execution of the powers herein expressly granted. IN WITNESS WHEREOF, the undersigned has hereunto set the undersigned’s hand this 20th day of March 2020.

Each undersigned Term Lender hereby irrevocably and unconditionally (i) consents to convert 100% of the outstanding principal amount of the Term Loans held by such Term Lender (or such lesser amount allocated to such Lender by the Administrative Agent) into a Term B-1 Loan in a like principal amount via a cashless roll and (ii) consents to the terms of the Amendment and the Amended Credit Agreement. IN WITNESS WHEREOF, the undersigned has caused this Consent to be executed and delivered by a duly authorized officer.

A379099 State of California OFFICE OF THE SECRETARY OF STATE CORPORATION DIVISION I, MARCH FONG EU, Secretary of State of the State of California, hereby certify: That the annexed transcript has been compared with the corporate record on file in this office, of which it purports to be a copy, and that same is full, true and correct. IN WITNESS WHEREOF, I execute this certificate and affix the Great Seal of the State of California this NOV 22 1989 [ILLEGIBLE] Secretary of State SEC/STATE FORM CE.107 86 40888

VI NO PREFERENCES, PRIVILEGES, RESTRICTIONS No distinction shall exist between the share of the corporation or the holders thereof. IN WITNESS WHEREOF, the undersigned, who are the incorporators, and the above-named first directors of this corporation, have executed these Articles of Incorporation of November 18 , 1976. [ILLEGIBLE] EDWARD C. GOOCH, Incorporator [ILLEGIBLE] DANNY O. VALLOND, Incorporator [ILLEGIBLE] SANDRA V. GOOCH, Incorporator [ILLEGIBLE] DONNA L. VALLOND, Incorporator [ILLEGIBLE] EDWARD LONNEGREN, JR., Incorporator State of California ) ) ss. County of Los Angeles ) On this 18 day of November, in the year 1976, before me. LEWIS W. BOIES, JR., a notary public, in and for said county and state, residing therein, duly commissioned and sworn, personally appeared EDWARD C. GOOCH, DANNY O. VALLOND, SANDRA V. GOOCH, DONNA L. VALLOND, AND EDWARD LONNEGREN, JR., known to me to be the persons whose names are subscribed to the within instrument, and acknowledged to me that they executed the same. IN WITNESS WHEREOF, I have hereunto set my hand and affixed my official seal the day and year in this certificate first above written. [ILLEGIBLE] [SEAL] LEWIS W. BOIES, JR., Notary Public -3-

State of California OFFICE OF THE SECRETARY OF STATE. I, MARCH FONG EU, Secretary of State of the State of California, hereby certify: That the annexed transcript has been compared with the record on file in this office, of which it purports to be a copy, and that same is full, true and correct. IN WITNESS WHEREOF, I execute this certificate and affix the Great Seal of the State of California this DEC 10 1976 [ILLEGIBLE] Secretary of State SEC/STATE FORM CE-107 (REV. 1.75) OSP

On this 7th day of September, 2011 before me personally appeared Jonathan W. Berger known or proven to me to be the Chief Executive Officer of the entity executing the foregoing instrument (“Entity”) and Katherine M. Hayes known or proven to me to be the Treasurer of the Entity and they acknowledge said instrument to be the free and voluntary act and deed of said Entity, for the uses and purposes therein mentioned and on oath stated that the seal affixed is the seal of said Entity and that it was affixed and that they executed said instrument by authority of the Entity IN WITNESS WHEREOF, I have hereunto set my hand and affixed my OFFICIAL SEAL the day and year first above written.

On this 7th day of September, 2011before me personally appeared Paul E. Dinquel known or proven to me to be the Vice President of the entity executing the foregoing instrument (“Entity”) and Susan M. Williamsknown or proven to me to be the Secretary of the Entity and they acknowledge said instrument to be the free and voluntary act and deed of said Entity, for the uses and purposes therein mentioned and on oath stated that the seal affixed is the seal of said Entity and that it was affixed and that they executed said instrument by authority of the Entity IN WITNESS WHEREOF, I have hereunto set my hand and affixed my OFFICIAL SEAL the day and year first above written.

On this 7th day of September, 2011before me personally appeared Jonathan W. Berger known or proven to me to be the President of the entity executing the foregoing instrument (“Entity”) and Ellen Parker Burke known or proven to me to be the Secretary of the Entity and they acknowledge said instrument to be the free and voluntary act and deed of said Entity, for the uses and purposes therein mentioned and on oath stated that the seal affixed is the seal of said Entity and that it was affixed and that they executed said instrument by authority of the Entity IN WITNESS WHEREOF, I have hereunto set my hand and affixed my OFFICIAL SEAL the day and year first above written.

On this 7th day of September, 2011 before me personally appeared Catherine Hoffman known or proven to me to be the President of the entity executing the foregoing instrument (“Entity”) and Giovanna O’Malleyknown or proven to me to be the Secretary of the Entity and they acknowledge said instrument to be the free and voluntary act and deed of said Entity, for the uses and purposes therein mentioned and on oath stated that the seal affixed is the seal of said Entity and that it was affixed and that they executed said instrument by authority of the Entity IN WITNESS WHEREOF, I have hereunto set my hand and affixed my OFFICIAL SEAL the day and year first above written.

IN WITNESS WHEREOF, the undersigned Investor hereby executes, delivers, joins in and agrees to be bound by (i) (A) the Securities Purchase Agreement by and between OvaScience, Inc. and the Investors (as defined therein) to which this Omnibus Signature Page is attached as an Investor thereunder and (B) the Registration Rights Agreement, attached to the Securities Purchase Agreement, by and among the Company and the Investors, which, together with all counterparts of such agreements and signature pages of other parties to such agreements, shall constitute one and the same document in accordance with the terms of such agreements, and (ii) elects to purchase for the number of Shares set forth below.